The use of β-diketone and cyanomethylene reagents for the synthesis of heterocyclic compounds and their fused derivatives with anti-tumor activities / by Hanan Maged Labib ; Supervisors Prof. Dr. Rafat Milad Mohareb, Prof. Dr. Refaat Ibrahim Naseem.

By:

Hanan Maged Labib [preparation.]

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TextLanguage: English Summary language: English, Arabic Producer: 2024Description: 218 pages : illustrations ; 25 cm. + CDContent type:

text

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Unmediated

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volume

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استخدام كواشف البيتا ثنائى الكيتون وسيانوالمثيلين النشطة لتحضير مركبات غير متجانسة الحلقة ومشتاقاتها الملتحمة كمضادات للأورام النشطة [Added title page title]

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547.59

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Issues also as CD.

Dissertation note: Thesis (Ph.D)-Cairo University, 2024. Summary: In this thesis we worked on synthesizing new heterocyclic compounds using B-diketones and cyanomethylene reagents. The synthetic schemes involved multicomponent reactions. Gewald’s thiophene synthesis was also involved to produce biologically active fused thiophene compounds. Anti-proliferative evaluations and inhibitions for the new synthesized compounds and their fused derivatives towards selected cancer cell lines were carried out along with foretinib as the positive control. The results revealed that many of the new compounds have high inhibition. This opens the way for more research especially in the drugs synthesis fieldSummary: ﻓﻲ ھﺬه اﻟﺮﺳﺎﻟﺔ، ﻗﻤﻨﺎ ﺑﺘﺤﻀﯿﺮ ﻣﺮﻛﺒﺎت ﻏﯿﺮ ﻣﺘﺠﺎﻧﺴﺔ اﻟﺤﻠﻘﺔ ﺑﺎﺳﺘﺨﺪام اﻟﺒﯿﺘﺎ ﺛﻨﺎﺋﻲ اﻟﻜﯿﺘﻮن و اﻟﺴﯿﺎﻧﻮﻣﯿﺜﯿﻠﯿﻦ. ﺗﻀﻤﻨﺖ اﻟﻤﺨﻄﻄﺎت ﺗﻔﺎﻋﻼت ﻣﺘﻌﺪدة اﻟﻤﻜﻮﻧﺎت.اﯾﻀﺎ ﺗﻢ اﺳﺘﺨﺪام ﺗﻔﺎﻋﻞ Gewald’s ﻟﺘﺤﻀﯿﺮ ﻣﺮﻛﺒﺎت اﻟﺜﯿﻮﻓﯿﻦ اﻟﻨﺸﻄﺔ. ﺗﻢ ﺗﻘﯿﯿﻢ اﻟﻨﺸﺎط اﻟﻤﻀﺎد ﻟﻠﺘﻜﺎﺛﺮ و اﻟﺘﺜﺒﯿﻂ ﻟﻠﻤﺮﻛﺒﺎت اﻟﻤﺼﻨﻌﺔ ﺣﺪﯾﺜﺎ و ﻣﺸﺘﻘﺎﺗﮭﺎ ﻣﻘﺎﺑﻞ ﺧﻄﻮط اﻟﺨﻼﯾﺎ اﻟﺴﺮطﺎﻧﯿﺔ ﺟﻨﺒﺎ اﻟﻲ ﺟﻨﺐ ﻣﻊ foretinib ﻛﻌﻨﺼﺮ ﺗﺤﻜﻢ اﯾﺠﺎﺑﻲ. اظﮭﺮت اﻟﻨﺘﺎﺋﺞ ان اﻟﻤﺮﻛﺒﺎت ﻟﺪﯾﮭﺎ ﺗﺜﺒﯿﻂ ﻋﺎﻟﻲ. ھﺬا ﯾﻔﺘﺢ اﻟﻄﺮﯾﻖ ﻟﻤﺰﯾﺪ ﻣﻦ اﻟﺒﺤﺚ ﺧﺎﺻﺔ ﻓﻲ ﻣﺠﺎل ﺻﻨﺎﻋﺔ اﻟﺪواء

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Holdings
Item type	Current library	Home library	Call number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.10.Ph.D.2024.Ha.U (Browse shelf(Opens below))	Not for loan	01010110091256000

Thesis (Ph.D)-Cairo University, 2024.

Bibliography: pages 201-218.

In this thesis we worked on synthesizing new heterocyclic compounds using B-diketones and cyanomethylene reagents. The synthetic schemes involved multicomponent reactions. Gewald’s thiophene synthesis was also involved to produce biologically active fused thiophene compounds. Anti-proliferative evaluations and inhibitions for the new synthesized compounds and their fused derivatives towards selected cancer cell lines were carried out along with foretinib as the positive control. The results revealed that many of the new compounds have high inhibition. This opens the way for more research especially in the drugs synthesis field

ﻓﻲ ھﺬه اﻟﺮﺳﺎﻟﺔ، ﻗﻤﻨﺎ ﺑﺘﺤﻀﯿﺮ ﻣﺮﻛﺒﺎت ﻏﯿﺮ ﻣﺘﺠﺎﻧﺴﺔ اﻟﺤﻠﻘﺔ ﺑﺎﺳﺘﺨﺪام اﻟﺒﯿﺘﺎ ﺛﻨﺎﺋﻲ اﻟﻜﯿﺘﻮن و اﻟﺴﯿﺎﻧﻮﻣﯿﺜﯿﻠﯿﻦ. ﺗﻀﻤﻨﺖ اﻟﻤﺨﻄﻄﺎت
ﺗﻔﺎﻋﻼت ﻣﺘﻌﺪدة اﻟﻤﻜﻮﻧﺎت.اﯾﻀﺎ ﺗﻢ اﺳﺘﺨﺪام ﺗﻔﺎﻋﻞ Gewald’s ﻟﺘﺤﻀﯿﺮ ﻣﺮﻛﺒﺎت اﻟﺜﯿﻮﻓﯿﻦ اﻟﻨﺸﻄﺔ. ﺗﻢ ﺗﻘﯿﯿﻢ اﻟﻨﺸﺎط اﻟﻤﻀﺎد ﻟﻠﺘﻜﺎﺛﺮ
و اﻟﺘﺜﺒﯿﻂ ﻟﻠﻤﺮﻛﺒﺎت اﻟﻤﺼﻨﻌﺔ ﺣﺪﯾﺜﺎ و ﻣﺸﺘﻘﺎﺗﮭﺎ ﻣﻘﺎﺑﻞ ﺧﻄﻮط اﻟﺨﻼﯾﺎ اﻟﺴﺮطﺎﻧﯿﺔ ﺟﻨﺒﺎ اﻟﻲ ﺟﻨﺐ ﻣﻊ foretinib ﻛﻌﻨﺼﺮ ﺗﺤﻜﻢ اﯾﺠﺎﺑﻲ. اظﮭﺮت اﻟﻨﺘﺎﺋﺞ ان اﻟﻤﺮﻛﺒﺎت ﻟﺪﯾﮭﺎ ﺗﺜﺒﯿﻂ ﻋﺎﻟﻲ. ھﺬا ﯾﻔﺘﺢ اﻟﻄﺮﯾﻖ ﻟﻤﺰﯾﺪ ﻣﻦ اﻟﺒﺤﺚ ﺧﺎﺻﺔ ﻓﻲ ﻣﺠﺎل ﺻﻨﺎﻋﺔ اﻟﺪواء

جامعة القاهرة

المكتبة المركزية الجديدة

مكتبة جامعة القاهرة الأهلية

The use of β-diketone and cyanomethylene reagents for the synthesis of heterocyclic compounds and their fused derivatives with anti-tumor activities / by Hanan Maged Labib ; Supervisors Prof. Dr. Rafat Milad Mohareb, Prof. Dr. Refaat Ibrahim Naseem.