Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry

Part I: Facile one-pot, three-component synthesis of novel series of bis(2-amino-3- cyano-4H-chromene), bis((2-amino-3-cyanopyrano[3,2-c]chromene, 6-amino-5-cyano- 1,4-dihydropyrano[2,3-c]pyrazole and bis(2,7-diamino-3,4,6-tricyanopyrazolo[1,5- a]pyridine) derivatives linked to thieno[2,3-b]thiophene-2,5-dicarboxylate core via ether as well as ester linkages were performed via Michael addition reaction. Part II: A novel series of bis(hexahydroacridine-1,8-diones), bis(tetrahydrodipyrazolo[3,4-b:4',3'-e]pyridines) and bis(pyrimido[4,5-b]quinolines) incorporating thieno[2,3-b]thiophenes core via ether as well as ester linkages were prepared via Hantzsch like reaction. All the compounds showed varying degree of Ü- glucosidase inhibition, compound 7c showed promising inhibitory activity. Part III: A synthesis of novel bis(thiazoles) as well as bis(thiadiazoles) each linked to thienothiophene moiety from the corresponding bis(aldehyde thiosemicarbazones) is reported. The bis(aldehyde thiosemicarbazones) were obtained by condensation of the appropriate bis(aldehydes) with thiosemicarbazide. Part IV: Novel bis(tetrahydro-[1,2,4]triazolo[3,4-a]isoquinolin-3-yl)-3-arylprop-2-en-1- one) derivatives were synthesized The novel compounds were screened for their cytotoxicity against cancer cell lines. Also, the compounds were screened for their antibacterial activities

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