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Effect of insulin and phosphodiesterase type - 5 inhibitor (sildenafil) on aromatase level and uterine function in streptozotocin - induced diabetic female rats / Safaa Mohammed Abdelwahab ; Supervised Alaa Eldin Amin Afifi , Hanan Abdelaziz Mubarak , Dina Sabry

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Safaa Mohammed Abdelwahab , 2014Description: 141 P. : charts ; 25cmOther title:
  • تأثير الإنسولين و العقار المثبط لإنزيم فوسفوداى إستريز٥ (السيلدنافيل) على مستوى الأروماتيز و وظائف الرحم فى إناث الفئران المصابة بداء السكرى الناجم عن إعطاء عقار الإستربتوزوتوسين [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology Summary: Type I Diabetes Mellitus (DM) is associated with multiple reproductive abnormalities and hypoestrogenemia. This study aimed to assess the effect of diabetes on aromatase enzyme gene expression in ovarian and uterine tissues, as well as, its effect on the height of uterine contractions. Also, to identify the possible therapeutic effects of insulin and sildenafil on both the aromatase enzyme level and the height of uterine contractions. Fifty female rats divided into five groups, ten for each, Group I: normal control rats, Group II: untreated streptozotocin-induced diabetic rats, Group III: insulin - treated diabetic, Group IV: phosphodiesterase type 5 inhibitor (PDE5i)-sildenafil-treated diabetic rats and group V: Combined PDE5i (sildenafil) and insulin - treated diabetic rats. Fasting glucose, fasting insulin and estrogen were measured in serum. Aromatase enzyme gene expression was measured in both ovarian and uterine tissues. Peak heights of spontaneous uterine contractions were recorded
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.30.M.Sc.2014.Sa.E (Browse shelf(Opens below)) Not for loan 01010110065691000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.30.M.Sc.2014.Sa.E (Browse shelf(Opens below)) 65691.CD Not for loan 01020110065691000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology

Type I Diabetes Mellitus (DM) is associated with multiple reproductive abnormalities and hypoestrogenemia. This study aimed to assess the effect of diabetes on aromatase enzyme gene expression in ovarian and uterine tissues, as well as, its effect on the height of uterine contractions. Also, to identify the possible therapeutic effects of insulin and sildenafil on both the aromatase enzyme level and the height of uterine contractions. Fifty female rats divided into five groups, ten for each, Group I: normal control rats, Group II: untreated streptozotocin-induced diabetic rats, Group III: insulin - treated diabetic, Group IV: phosphodiesterase type 5 inhibitor (PDE5i)-sildenafil-treated diabetic rats and group V: Combined PDE5i (sildenafil) and insulin - treated diabetic rats. Fasting glucose, fasting insulin and estrogen were measured in serum. Aromatase enzyme gene expression was measured in both ovarian and uterine tissues. Peak heights of spontaneous uterine contractions were recorded

Issued also as CD

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