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Development of mucoadhesive buccal delivery system for a corticosteroid drug / Hend Ibrahim Shahin ; Supervised Mahmoud M. Ghorab , Hussein O. Ammar

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Hend Ibrahim Shahin , 2014Description: 219 P. : facsimiles ; 25cmOther title:
  • تطوير نظام لاصق للمخاط الفموى لدواء كورتيكوستيرُويدى [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: The main objective of the thesis was to develop and evaluate mucoadhesive buccal film containing fluticasone propionate for management of severe erosive mouth lesions. The films were prepared by solvent casting technique using different polymeric blends. The prepared mucoadhesive films were subjected to extensive physicochemical evaluation, as well as studying their in-vitro drug release and mucoadhesion residence time which revealed acceptable drug content, release profiles and mucoadhesion time. The optimized formulations were subjected to DSC thermograms, XRD and the effect of storage studies. Finally, in vivo performance of the optimized formulations were evaluated in human volunteers by analysis of salivary drug concentration over 10 hrs where the pharmacokinetic parameters were calculated and compare to prepared mouthwash containing the same dose as in the mucoadhesive films
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2014.He.D (Browse shelf(Opens below)) Not for loan 01010110065241000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2014.He.D (Browse shelf(Opens below)) 65241.CD Not for loan 01020110065241000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

The main objective of the thesis was to develop and evaluate mucoadhesive buccal film containing fluticasone propionate for management of severe erosive mouth lesions. The films were prepared by solvent casting technique using different polymeric blends. The prepared mucoadhesive films were subjected to extensive physicochemical evaluation, as well as studying their in-vitro drug release and mucoadhesion residence time which revealed acceptable drug content, release profiles and mucoadhesion time. The optimized formulations were subjected to DSC thermograms, XRD and the effect of storage studies. Finally, in vivo performance of the optimized formulations were evaluated in human volunteers by analysis of salivary drug concentration over 10 hrs where the pharmacokinetic parameters were calculated and compare to prepared mouthwash containing the same dose as in the mucoadhesive films

Issued also as CD

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