header
Local cover image
Local cover image
Image from OpenLibrary

Discovery of new selective antagonists for cell apoptosis inhibitor proteins as novel anticancer agents / Ayat Gamal Ali Ahmed ; Supervised Abdou Osman Abdelhamid , Mervat Elsayed Mohamed , Magda Fikry Mahmoud

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ayat Gamal Ali Ahmed , 2017Description: 175 P. : charts , facsimiles , photographs ; 25cmOther title:
  • إكتشاف مضادات إنتقائية جديدة للبروتينات المثبطة لعملية الموت الممنهج للخلايا كعوامل جديدة مضادة للسرطان [Added title page title]
Subject(s): Online resources: Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry Summary: In this study, four new adamantane thiadiazole derivatives (ATDs) were designed and theoretically tested for their binding affinities to a model of an apoptosis inhibitor protein using molecular modeling. ATD-4, that showed the highest binding affinity, was synthesized, characterized and screened for its cytotoxic activity against different cancer cell lines as well as normal cell line using 5-fluorouracil as a reference organic drug. Inducing apoptosis in lung carcinoma cell line was studied by various biochemical and morphological methods. Results indicate that ATD-4 exerted its cytotoxic activity against A549 cells through the induction of the intrinsic (mitochondrial) apoptotic pathway
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.Ph.D.2017.Ay.D (Browse shelf(Opens below)) Not for loan 01010110073719000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.Ph.D.2017.Ay.D (Browse shelf(Opens below)) 73719.CD Not for loan 01020110073719000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry

In this study, four new adamantane thiadiazole derivatives (ATDs) were designed and theoretically tested for their binding affinities to a model of an apoptosis inhibitor protein using molecular modeling. ATD-4, that showed the highest binding affinity, was synthesized, characterized and screened for its cytotoxic activity against different cancer cell lines as well as normal cell line using 5-fluorouracil as a reference organic drug. Inducing apoptosis in lung carcinoma cell line was studied by various biochemical and morphological methods. Results indicate that ATD-4 exerted its cytotoxic activity against A549 cells through the induction of the intrinsic (mitochondrial) apoptotic pathway

Issued also as CD

There are no comments on this title.

to post a comment.

Click on an image to view it in the image viewer

Local cover image