header
Image from OpenLibrary

Evaluation of survivin expression in breast cancer : Histopathological and immunohistochemical study / Rabab Radi Gomaa Mahmoud ; Supervised Solafa Ameen Alabyad , Hanan Hassan Mohammed , Rasha Ahmed Khairy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Rabab Radi Gomaa Mahmoud , 2016Description: 165 P. : charts , facsimiles ; 25cmOther title:
  • تقييم التعبير عن "سرفيفين" فى سرطان الثدي : دراسة هستوباثولوجية و كميائية هستومناعية [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology Summary: Background: Breast cancer (BC) is the most common type of cancer among women world-wide and leading cause of cancer related deaths. As normal breast development is controlled by a balance between cell proliferation and apoptosis, and there is also strong evidence that tumor growth is not just a result of uncontrolled proliferation but also of reduced apoptosis. Tumor cells can acquire resistance to apoptosis by expression of certain anti {u2013} apoptopic proteins called Inhibitors of Apoptosis Proteins (IAP). Survivin is the smallest IAP family member and has a dual activity as both an inhibitor of apoptosis and regulator of cell cycle. Objectives: Investigation of immunohistochemical expression of survivin in cases of female BC and correlation of this expression with the clinico-pathological aspects of the tumors. Materials and methods: Fifty formalin fixed paraffin embedded BC tissue sections were randomly collected. All the available data were collected from the patients{u2019} reports. The paraffin blocks were sectioned and stained with hematoxylin & eosin stains for histologic evaluation. Additional sections were immunostained with survivin. Results: Nuclear survivin expression was detected in 66% of cases and it was associated with some of the negative prognostic factors although it didn't reach statistical significance (p-values were found to be higher than 0.05) where higher rate of survivin expression showed apparent direct association with IDC-NST histologic type, presence of insitu component, ER and PR negativity and high Ki-67 proliferation index as well as Her 2 enriched molecular subtype. Conclusion: Survivin expression is detected in 66% of breast carcinoma cases and is likely to be associated with poor prognosis making it a potential target for treatment
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.M.Sc.2016.Ra.E (Browse shelf(Opens below)) Not for loan 01010110070592000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.M.Sc.2016.Ra.E (Browse shelf(Opens below)) 70592.CD Not for loan 01020110070592000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology

Background: Breast cancer (BC) is the most common type of cancer among women world-wide and leading cause of cancer related deaths. As normal breast development is controlled by a balance between cell proliferation and apoptosis, and there is also strong evidence that tumor growth is not just a result of uncontrolled proliferation but also of reduced apoptosis. Tumor cells can acquire resistance to apoptosis by expression of certain anti {u2013} apoptopic proteins called Inhibitors of Apoptosis Proteins (IAP). Survivin is the smallest IAP family member and has a dual activity as both an inhibitor of apoptosis and regulator of cell cycle. Objectives: Investigation of immunohistochemical expression of survivin in cases of female BC and correlation of this expression with the clinico-pathological aspects of the tumors. Materials and methods: Fifty formalin fixed paraffin embedded BC tissue sections were randomly collected. All the available data were collected from the patients{u2019} reports. The paraffin blocks were sectioned and stained with hematoxylin & eosin stains for histologic evaluation. Additional sections were immunostained with survivin. Results: Nuclear survivin expression was detected in 66% of cases and it was associated with some of the negative prognostic factors although it didn't reach statistical significance (p-values were found to be higher than 0.05) where higher rate of survivin expression showed apparent direct association with IDC-NST histologic type, presence of insitu component, ER and PR negativity and high Ki-67 proliferation index as well as Her 2 enriched molecular subtype. Conclusion: Survivin expression is detected in 66% of breast carcinoma cases and is likely to be associated with poor prognosis making it a potential target for treatment

Issued also as CD

There are no comments on this title.

to post a comment.