Assessment of some medicinal plants for treatment of obesity / Riham Adel Elshiekh ; Supervised Mohamed S. Hifnawy , Essam A. Abdelsattar , Dalia A. Almahdy

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Riham Adel Elshiekh

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Material type: Text

TextLanguage: English Publication details: Cairo : Riham Adel Elshiekh , 2019Description: 195 P. : charts , facsimiles ; 25cmOther title:

تقييم بعض النباتات الطبية لعلاج السمنة [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy Summary: The total methanolic and aqueous extracts of five plants (viz: Caralluma quadrangula, Caralluma tuberculata, Hibiscus shizopetalous, Hibiscus sabdariffa (white variety) and Solenostemma argel) were tested for their inhibitory activity against pancreatic lipase, Ü-amylase and Ü-glucosidase enzymes, along with their anti-oxidant potential via two different complementary methods; DPPH (1, 1-Diphenyl-2-picrylhydrazyl) radical scavenging activity and iron reducing power assays. The plants extracts were also estimated quantitatively for their total phenolic, flavonoid, tannin and steroidal contents. The results showed that Solenostemma argel was the most active among the selected plants. An optimized extraction method was developed for S. argel based on its enzyme inhibitory activity to ensure maximum biological activity. The methylene chloride and n-butanol fractions, in addition to, seven isolated compounds viz: sterols, pregnane glycoside and flavonoid aglycones and glycosides from S. argel were further evaluated. In-vivo biological study revealed that S. argel is a promising Egyptian natural drug, rich in pregnane glycosides, and could be considered a new therapeutic candidate targeting obesity. The ethanolic extract was also standardized using LC{u2013}MS analysis for its content of stemmoside C

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.08.07.Ph.D.2019.Ri.A (Browse shelf(Opens below))		Not for loan		01010110078989000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.08.07.Ph.D.2019.Ri.A (Browse shelf(Opens below))	78989.CD	Not for loan		01020110078989000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy

The total methanolic and aqueous extracts of five plants (viz: Caralluma quadrangula, Caralluma tuberculata, Hibiscus shizopetalous, Hibiscus sabdariffa (white variety) and Solenostemma argel) were tested for their inhibitory activity against pancreatic lipase, Ü-amylase and Ü-glucosidase enzymes, along with their anti-oxidant potential via two different complementary methods; DPPH (1, 1-Diphenyl-2-picrylhydrazyl) radical scavenging activity and iron reducing power assays. The plants extracts were also estimated quantitatively for their total phenolic, flavonoid, tannin and steroidal contents. The results showed that Solenostemma argel was the most active among the selected plants. An optimized extraction method was developed for S. argel based on its enzyme inhibitory activity to ensure maximum biological activity. The methylene chloride and n-butanol fractions, in addition to, seven isolated compounds viz: sterols, pregnane glycoside and flavonoid aglycones and glycosides from S. argel were further evaluated. In-vivo biological study revealed that S. argel is a promising Egyptian natural drug, rich in pregnane glycosides, and could be considered a new therapeutic candidate targeting obesity. The ethanolic extract was also standardized using LC{u2013}MS analysis for its content of stemmoside C

Issued also as CD

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