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Efficacy of pyrroloquinoline quinone (PQQ)loaded on nanofibers after experimental spinal cord injury in rats / Sara Ibrahim Mohamed ; Supervised Mohamed Ismail Mohamed , Taghride Abdel Rahman , Ahmed Abdellatif Abdelmaged

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Sara Ibrahim Mohamed , 2021Description: 126 P. : charts , facsimiles ; 25cmOther title:
  • فاعلية البيرولوكينولين كينون المحمول على ألياف نانوية عقب إصابة الحبل الشوكى تجريببا فى الجرذان [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology Summary: The aim of this study was to investigate the neuroprotective effects of PQQ loaded on coaxial nanofibers following spinal cord injury in adult female Sprague Dawley rats (n = 100). The animals were divided into five groups: control, sham, SCI, unloaded nanofibers, and nanofibers loaded with PQQ.SCI caused a significant increase in the levels of IL-1Ý, IL-6, TNF-Ü, NF-kB, NO, iNOS and MDA. On the other hand, the injury induced a significant decrease in the level of IL-10 and the SOD and CAT activities in injured spinal cord tissue. Treatment of rats post SCI with unloaded nanofibers improved most of the above mentioned biochemical parameters and shifted them toward the sham group values.The treatment of SCI rats with PQQ loaded on coaxial nanofibers ameliorated all the investigated biochemical parameters. PQQ induced a decrease in the levels of IL-1Ý, IL-6, TNF-Ü, NF-kB, NO, iNOS and MDA, while caused an increase in the level of IL-10 and the activities of SOD and CAT in injured spinal cord tissue. However, the present study provides new insight into the anti-inflammatory and anti-oxidative stress mechanisms of PQQ action, so further studies are required to clarify the role of PQQ loaded on coaxial nanofibers in SCI treatment
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.Ph.D.2021.Sa.E (Browse shelf(Opens below)) Not for loan 01010110084707000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.Ph.D.2021.Sa.E (Browse shelf(Opens below)) 84707.CD Not for loan 01020110084707000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology

The aim of this study was to investigate the neuroprotective effects of PQQ loaded on coaxial nanofibers following spinal cord injury in adult female Sprague Dawley rats (n = 100). The animals were divided into five groups: control, sham, SCI, unloaded nanofibers, and nanofibers loaded with PQQ.SCI caused a significant increase in the levels of IL-1Ý, IL-6, TNF-Ü, NF-kB, NO, iNOS and MDA. On the other hand, the injury induced a significant decrease in the level of IL-10 and the SOD and CAT activities in injured spinal cord tissue. Treatment of rats post SCI with unloaded nanofibers improved most of the above mentioned biochemical parameters and shifted them toward the sham group values.The treatment of SCI rats with PQQ loaded on coaxial nanofibers ameliorated all the investigated biochemical parameters. PQQ induced a decrease in the levels of IL-1Ý, IL-6, TNF-Ü, NF-kB, NO, iNOS and MDA, while caused an increase in the level of IL-10 and the activities of SOD and CAT in injured spinal cord tissue. However, the present study provides new insight into the anti-inflammatory and anti-oxidative stress mechanisms of PQQ action, so further studies are required to clarify the role of PQQ loaded on coaxial nanofibers in SCI treatment

Issued also as CD

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